Role of prenatal microbiota in fetal programming

According to the concept of D. Barker, intrauterine period is decisive in programming postnatal pathology, which can manifest during life. Among factors fetal programming, microbiota plays an important role, but many aspects are still debatable.Objective: analysis and generalization literary data devoted study association between human body microorganisms, their characteristics pregnancy role health pathology.According literature analysis, article provides on non-sterility environment ways its formation. The dynamics features “healthy” biotopes intestines, vagina, mouth placenta considered. main fetus colonization by microorganisms described, particular, a major given oral microflora. effects prenatal physiological complicated pregnancy, namely preeclampsia, gestational diabetes, miscarriage discussed.Evidence provided that microbial metabolites capable epigenomic modifications alter metabolism. This further realized diseases civilization. In addition, there 360 times more bacterial genes than genes. Therefore, they called “second genome” human, be changed according needs. Modern research points essential importance maternal impact formation microflora pathology this process begins utero. Maternal normal pathological conditions has direct indirect effect through immune reactions or penetrating placenta.Conclusions. metabolic processes newborn extremely important. Microbiota also significant pathophysiological programmed pathology. development correct preventive therapeutic measures modify periods active should perspective for research. will allow it corrected taking into account individual biotopes.